Antibiotics that may be used to treat gonorrhea include :
· Amoxicillin 2 g plus probenecid 1 g orally
· Ampicillin 2 to 3 g plus probenecid 1 g orally
· Azithromycin 2 g orally
· Cefixime 400 mg orally
· Cefotaxime 500 mg by intramuscular injection
· Cefoxitin 2 g by intramuscular injection, plus probenecid 1 g orally
· Cefpodoxime (Vantin) 400 mg orally
· Ceftriaxone (Rocephin) 125 to 250 mg by intramuscular injection
· Ciprofloxacin 500 mg orally
· Levofloxacin 250 mg orally
· Ofloxacin 400 mg orally
· Spectinomycin 2 g by intramuscular injection
These drugs are all given as a single dose.
The level of tetracycline resistance in Neisseria gonorrhœae is now so high as to make it completely ineffective in most parts of the world.
The fluoroquinolones (ciprofloxacin, ofloxacin, levofloxacin) cannot be used in pregnancy. It is important to refer all sexual partners to be checked for gonorrhea to prevent spread of the disease and to prevent the patient from becoming re-infected with gonorrhea. Patients should also be offered screening for other sexually transmitted infections. In areas where co-infection with chlamydia is common, doctors may prescribe a combination of antibiotics, such as ceftriaxone with doxycycline or azithromycin, to treat both diseases.
Penicillin is ineffective at treating rectal gonorrhea : this is because other bacteria within the rectum produce β-lactamases that destroy penicillin. All current treatments are less effective at treating gonorrhea of the throat, so the patient must be rechecked by throat swab 72 hours or more after being given treatment, and then retreated if the throat swab is still positive.
Although gonorrhea usually does not require follow-up (with the exception of rectal or pharyngeal disease), patients are usually advised to phone for results five to seven days after diagnosis to confirm that the antibiotic they received was likely to be effective. Patients are advised to abstain from sex during this time.
The above information thankfully comes from the en.wikipedia.orgat the following link.